Efficacy in cats of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, praziquantel, against induced infestations of Echinococcus multilocularis.
Identifieur interne : 000121 ( Main/Exploration ); précédent : 000120; suivant : 000122Efficacy in cats of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, praziquantel, against induced infestations of Echinococcus multilocularis.
Auteurs : Eric Tielemans [France] ; Coralie Manavella [France] ; Martin Visser [Allemagne] ; S. Theodore Chester [États-Unis] ; Joseph Rosentel [États-Unis]Source :
- Veterinary parasitology [ 1873-2550 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Antiparasitic Agents (administration & dosage), Cat Diseases (drug therapy), Cats, Drug Combinations, Echinococcosis (drug therapy), Echinococcosis (veterinary), Echinococcus multilocularis, Female, Ivermectin (administration & dosage), Ivermectin (analogs & derivatives), Male, Methoprene (administration & dosage), Praziquantel (administration & dosage), Pyrazoles (administration & dosage), Random Allocation, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antiparasitic Agents, Ivermectin, Methoprene, Praziquantel, Pyrazoles.
- chemical , analogs & derivatives : Ivermectin.
- drug therapy : Cat Diseases, Echinococcosis.
- veterinary : Echinococcosis.
- Animals, Cats, Drug Combinations, Echinococcus multilocularis, Female, Male, Random Allocation, Treatment Outcome.
Abstract
Although foxes are the main reservoir of Echinococcus multilocularis, it is recognized that dogs and cats also may become infected. In cats the infection and egg production rates are usually low. Nevertheless, cats are a potential source of transmission of E. multilocularis. Due to the high human medical significance of E. multilocularis infection, it is important in endemic areas that owned cats are dewormed regularly. This paper presents the efficacy results of a new topical formulation, Broadline(®) (Merial) tested against E. multilocularis infection in cats. Two blinded laboratory studies were conducted to evaluate this novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel against E. multilocularis. In each study, purpose-bred cats were assigned randomly to two treatment groups of 10 cats each: one untreated control group and one group treated at the minimum therapeutic dose of 0.12 mL/kg bodyweight to deliver 10mg fipronil, 12 mg (S)-methoprene, 0.5mg eprinomectin and 10mg praziquantel/kg bodyweight. The cats were inoculated orally with E. multilocularis protoscolices, 22 or 23 days before treatment. Based on necropsy and intestinal worm count, 8 or 11 days after treatment, the two studies confirmed 100% efficacy of Broadline(®) against adult E. multilocularis.
DOI: 10.1016/j.vetpar.2014.02.034
PubMed: 24703072
Affiliations:
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Electronic address: eric.tielemans@merial.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Merial SAS, Centre de Recherche de Saint-Vulbas, 01150 Saint-Vulbas</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Vulbas</settlement></placeName></affiliation></author><author><name sortKey="Manavella, Coralie" sort="Manavella, Coralie" uniqKey="Manavella C" first="Coralie" last="Manavella">Coralie Manavella</name><affiliation wicri:level="3"><nlm:affiliation>Merial SAS, Centre de Recherche de Saint-Vulbas, 01150 Saint-Vulbas, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Merial SAS, Centre de Recherche de Saint-Vulbas, 01150 Saint-Vulbas</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Vulbas</settlement></placeName></affiliation></author><author><name sortKey="Visser, Martin" sort="Visser, Martin" uniqKey="Visser M" first="Martin" last="Visser">Martin Visser</name><affiliation wicri:level="1"><nlm:affiliation>Merial GmbH, Kathrinenhof Research Center, 83101 Rohrdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Merial GmbH, Kathrinenhof Research Center, 83101 Rohrdorf</wicri:regionArea><wicri:noRegion>83101 Rohrdorf</wicri:noRegion><wicri:noRegion>83101 Rohrdorf</wicri:noRegion><wicri:noRegion>83101 Rohrdorf</wicri:noRegion></affiliation></author><author><name sortKey="Theodore Chester, S" sort="Theodore Chester, S" uniqKey="Theodore Chester S" first="S" last="Theodore Chester">S. 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In cats the infection and egg production rates are usually low. Nevertheless, cats are a potential source of transmission of E. multilocularis. Due to the high human medical significance of E. multilocularis infection, it is important in endemic areas that owned cats are dewormed regularly. This paper presents the efficacy results of a new topical formulation, Broadline(®) (Merial) tested against E. multilocularis infection in cats. Two blinded laboratory studies were conducted to evaluate this novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel against E. multilocularis. In each study, purpose-bred cats were assigned randomly to two treatment groups of 10 cats each: one untreated control group and one group treated at the minimum therapeutic dose of 0.12 mL/kg bodyweight to deliver 10mg fipronil, 12 mg (S)-methoprene, 0.5mg eprinomectin and 10mg praziquantel/kg bodyweight. The cats were inoculated orally with E. multilocularis protoscolices, 22 or 23 days before treatment. Based on necropsy and intestinal worm count, 8 or 11 days after treatment, the two studies confirmed 100% efficacy of Broadline(®) against adult E. multilocularis.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Géorgie (États-Unis)</li><li>Rhône-Alpes</li></region><settlement><li>Saint-Vulbas</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Tielemans, Eric" sort="Tielemans, Eric" uniqKey="Tielemans E" first="Eric" last="Tielemans">Eric Tielemans</name></region><name sortKey="Manavella, Coralie" sort="Manavella, Coralie" uniqKey="Manavella C" first="Coralie" last="Manavella">Coralie Manavella</name></country><country name="Allemagne"><noRegion><name sortKey="Visser, Martin" sort="Visser, Martin" uniqKey="Visser M" first="Martin" last="Visser">Martin Visser</name></noRegion></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Theodore Chester, S" sort="Theodore Chester, S" uniqKey="Theodore Chester S" first="S" last="Theodore Chester">S. 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